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neuro enca

NeUrologic Treatments

What is neurodegenerative disease?

Amyotrophic lateral sclerosis (ALS).
Motor Neuron Disease

In recent years there has been great interest in establishing the role of stem cell therapies in various diseases. More than differentiation into neurons and replacement of dead neurons, research is currently focused on exploiting the paracrine properties of neuroprotection, control of inflammation, and modulation of the immune system by transplanted stem cells (1). Although it is necessary to reinforce, through controlled clinical trials currently underway, the evidence of safety/efficacy, dose, type of cells, routes of administration, etc., the available information shows slowing of the progression of diseases such as multiple sclerosis, amyotrophic lateral sclerosis and Parkinson's disease.

The safety and effectiveness of stem cell-based regenerative medicine for the treatment of multiple sclerosis has reached such a level of evidence that recently the American Society for Stem Cell Transplantation Blood and Marrow has recommended including the severe forms of this disease among the indications for autologous hematopoietic stem cell transplantation, with which the academic and scientific world opens the clinical doors to explore the role of stem cells of other types (2 )

On the other hand, a review of 19 phase I/II studies on amyotrophic lateral sclerosis (ALS), which included 380 patients, confirms the safety (no events severe adverse events) and the feasibility of intravenous and intracerebral application of stem cells, although the effectiveness results cannot yet be considered conclusive (3,4). But the interest of the scientific community in this topic is such that by mid-2019 there were already 50 studies registered in ClinicalTrials on ALS+ stem cells.

The ability of stem cells to repair damage caused by Parkinson's disease (PD) has been demonstrated in vitro, and studies on the safety and effectiveness of treatment with stem cells in animal models of the disease are conclusive, a point that has authorized research in humans. now clinical evidence can be summarized as follows: i) safety studies of application in humans leave doubts: we are facing a therapeutic tool with a very low rate of undesirable effects related to what could be considered serious adverse effects; ii) evidence from effectiveness studies, although it is still decisive, stem cells are becoming increasingly strong as a therapy associated with improvement in the clinical condition, radiological images and neuropsychological scores of patients with PD(5- 7).

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Regenerative Medicine
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Stem Cells

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