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Orthopedic & Chronic Pain

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Orthopedic & Chronic Pain Treatments

What is Orthopedic Disease

Osteoporosis's disease.
Arthritis’s disease.
Osteoarthritis’s disease.
Rheumatoid Arthritis.
Knee Pain disease

Chronic orthopedic conditions, such as arthritis and bursitis, affect the musculoskeletal system – most commonly the bones or joints. They can cause pain and dysfunction, making even normal daily activities difficult. These conditions are different from orthopedic injuries, like a shoulder dislocation or broken bone, which are often due to sudden trauma. Unlike accidental or traumatic orthopedic injuries, chronic conditions tend to be progressive in nature, starting slowly and getting worse or evolving over time. They may be genetic or age-related, or they may be caused by overuse.

Osteoarticular disorders.


Osteoarticular disorders, such as osteoarthritis, chronic tendinopathies and fractures with bone loss, have been the most studied by regenerative medicine, which is currently positioned as a safe option and a good candidate to overcome functional limitation and pain. chronic to which some of these patients are condemned, since it is the only therapeutic tool whose tissue repair capacity has been demonstrated.
Conventional treatment of osteoarthritis shows only modest clinical benefits, while more than 40 published clinical trials report that intra-articular injection of stem cells with growth factors results in clear recovery of cartilage and clinical parameters (pain and functional limitation), imaging , arthroscopic and quality of life (1,2). For example, a 2019 meta-analysis, which included 33 investigations and 724 patients with osteoarthritis, shows that there was a significant improvement in pain and joint function, accompanied by regeneration of joint cartilage


In sports injuries that compromise the tendons and chronic tendinopathies, management traditionally includes analgesics, anti-inflammatories, physiotherapy and surgery, with partial responses and many undesirable effects. On the contrary, most of the published clinical studies show that the intralesional application of stem cells improves pain, joint performance and structural defects of the injured tendon

Some orthopedic conditions are curable, and some cannot currently be cured, but can be treated to reduce pain and improve quality of life. Getting an accurate diagnosis and targeted treatment can help reduce problems down the road – even in progressive conditions without a cure.

What regenerative medicine can do.

Orthopedic indications collectively represent a large clinical and economic burden, especially given the aging world population. To meet this area of unmet need, a wave of regenerative medicine therapies, including stem cells and other cell-based therapies, is currently in clinical development and anticipated to inundate the global market over the next few years.

Although intended to be transformative, orthopedic cell therapies face several practical opportunities and challenges. Such therapies could reduce the health care burden, in part by replacing traditional drug therapies and highly-invasive surgical interventions with single-dose treatments. However, therapy developers and providers must address hurdles from regulatory to reimbursement to commercial challenges before successful orthopedic cell therapies are available to patients.

Regulatory policies, reimbursement processes, and commercial requirements for orthopedic cell therapies differ across markets, and key health care stakeholders must address these differences well before a product launch. Pricing and reimbursement models for innovative therapies, like cell-based therapies in orthopedics, grow unclear, especially how health care systems will absorb potentially transformative and highly-needed, but costly, therapies.

Single administration therapies with relatively high upfront cost require more evidence to support their value for pricing and reimbursement than other health care products, and orthopedic cell therapies must do so based on patient quality of life and health care resource use, as opposed to improved survival, which is especially challenging. In addition, alternative financing and reimbursement models may be needed to support ongoing patient access and innovation. In the current article, we discuss global health policy issues and considerations for orthopedic cell therapy development and adoption.

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Regenerative Medicine
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Stem Cells

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