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Osteomuscular Diseases

What is Osteomuscular Disease

Carpal tunnel syndrome.
Tension neck syndrome.
Back pain

Musculoskeletal disorders (MSDs) are injuries or pain in the human musculoskeletal system, including the joints, ligaments, muscles, nerves, tendons, and structures that support limbs, neck and back. MSDs can arise from a sudden exertion (e.g., lifting a heavy object), or they can arise from making the same motions repeatedly repetitive strain, or from repeated exposure to force, vibration, or awkward posture.
Injuries and pain in the musculoskeletal system caused by acute traumatic events like a car accident or fall are not considered musculoskeletal disorders. MSDs can affect many different parts of the body including upper and lower back, neck, shoulders and extremities (arms, legs, feet, and hands).

The musculoskeletal (MSK) system is comprised of the bones, joints, tendons, ligaments and other connective tissues within the body of an organism to provide form, support, stability and movement. The structural and functional integrity of these distinctive parts is crucial for organ functioning, as well as for its integration with other systems.

The functioning of the MSK system influences complex inter-system connectivity, including from interactions between physical activity and the environment to interpersonal relationships and social integration. The status of the MSK impacts metabolic activities and overall health in individuals of all ages, as well as functional independence and cognitive preservation in the elderly

What can do Stem cells in Osteomuscular Disease ?

The identification and characterization of stem cells is introducing a paradigm shift in the field of orthopaedic surgery. Whereas in the past, diseased tissue was replaced with allograft material, current trends in research revolve around regenerating damaged tissue.

Muscle-derived stem cells have an application in regeneration of articular cartilage, bone, and skeletal muscle. These postnatal (ie, adult) stem cells can be readily isolated via muscle biopsy. They can display long-term proliferation, high self-renewal, and multipotent differentiation. They also can be genetically modified to secrete growth factors important to tissue healing, thereby functioning as implantable, long-lasting reservoirs for these molecules.

Taken together, this evidence suggests that muscle-derived stem cells are well suited for gene therapy and tissue engineering applications for the musculoskeletal system. Effective implementation of even just a few applications of muscle-derived stem cell-based tissue engineering has the potential to revolutionize the way certain musculoskeletal diseases are managed.

Source: NIH - National Librady of Medicine.

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